News & Events: Acute Rejection Assay

International Innovation, an online forum for the communication and dissemination of cutting-edge research, recently reported on the pioneering efforts of the Sarwal Lab to develop novel translational approaches for improving the management of kidney transplant patients and treating renal disease. The article reports on the lab's breakthrough assays, the kidney solid organ rejection test (kSORT) and the kidney spontaneous operational tolerance test (kSPOT), and their potential to revolutionize the way kidney transplant patients are managed after transplantation by predicting acute [...]

UCSF News reports on research led by Minnie Sarwal, MD, PhD, Director of the Sarwal Lab, in developing a  test for diagnosing and predicting acute rejection (AR) in kidney transplants, a finding that eventually could replace the need for biopsies and lead to earlier detection of AR and treatment. 'We have found a set of genes in blood that pick up inflammation and acute rejection in different solid organ transplants and thus can replace the need for an invasive biopsy in the future,' said senior author Minnie Sarwal, MD, PhD, Professor of Transplant Surgery at UCSF. 'This assay also [...]

UCSF News recently reported on research of the Sarwal Lab demonstrating pre-transplant antibody levels were associated with recurrence of FSGS.  Researchers at UC San Francisco and Rush University Medical Center, Chicago, may have found a predictor for a disorder affecting kidney transplant recipients that can accelerate organ failure, a discovery that eventually could allow for customized therapies and improved patient selection for transplant. The study of focal segmental glomerulosclerosis (FSGS), a devastating form of kidney disease, is in the Oct. 1 issue of Science Translational [...]