University of California San Francisco

Dr. Warren Gasper
Warren
Gasper
MD

Associate Professor of Surgery,
Division of Vascular and Endovascular Surgery
Department of Surgery, School of Medicine
Chief, Vascular Surgery Section,
San Francisco VA Health Care System
Director, Vascular Integrated Physiology and
Experimental Therapeutics (ViperX)
Associate Director, Vascular Surgery Integrated Residency Program

Academic Office:
400 Parnassus Ave, A581, Box 0222
San Francisco, CA 94143
Tel: 415-353-4366
Email: [email protected] 
Asst: [email protected]

Vascular Surgery Clinic:
400 Parnassus Ave, A501, Box 0957
San Francisco, CA 94143
Tel: 415-353-2357
Fax: 415-353-2669

Vascular Surgery Clinic at SFVA:
4150 Clement Street 
San Francisco, CA 94121
Tel: 415-221-4810 x25496 

    Biography

    My current research interests fall broadly into the categories of vein / vein graft physiology and advanced endovascular aneurysm therapies. Over the past 4 years I have been working with Dr Michael Conte and Dr Christopher Owens in the UCSF Division of Vascular and Endovascular Surgery on several projects involving vein graft physiology, which have lead to several presentations at national meetings as well as publications. We have found that after lower extremity bypass surgery most luminal dilation occurs early (30 days) and is typically complete by 3 months. However, the response is not uniform and it appears that a mixture of local factors (e.g. vein diameter and quality), biologic factors (e.g. preoperative hsCRP levels) and systemic factors (e.g. race, indication for bypass surgery) are involved in the remodeling response.
    My second major area of research interest is advanced endovascular therapies for aortic aneurysms. The development and widespread adoption of endovascular stent-grafts for infrarenal aortic aneurysms and thoracic aortic aneurysms have dramatically reduced the physiologic demands, complication rates and length of hospitalization for patients undergoing infrarenal or thoracic aortic aneurysm repairs compared to open techniques. However, aneurysms of thoracoabdominal, paravisceral and/or pararenal aorta require even more demanding operations with a higher rate of complications and longer hospitalizations. For the past 4 years I have worked with Dr. Timothy Chuter and Dr. Linda Reilly in the UCSF Division of Vascular and Endovascular Surgery to develop the multi-branched endovascular thoracoabdominal aneurysm repair technique. The technique is being studied under an FDA IDE in a CHR-approved study at UCSF and the San Francisco VA. As the co-principal investigator, I am responsible for overseeing the regulatory and subject care activities for the study at the San Francisco VA. This work has included consultations in the outpatient clinic, planning and performing the multi-branched endovascular repairs and analyzing the results of the study.

    Education

    Institution Degree Dept or School End Date
    University of California, San Francisco Vascular Surgeyr Fellowship School of Medicine 2013
    University of California, San Francisco Vascular Surgery Fellowship School of Medicine 2011
    University of California, San Francisco General Surgery Residency School of Medicine 2010
    Univeristy of Maryland, Baltimore M.D. School of Medicine 2003
    Bowdoin College A.B Biochemistry & German 1999

    Awards & Honors

    Award Conferred By Date
    Lim/Thomas Excellence in Teaching Award UCSF Department of Surgery Chief Residents 2018
    Excellence in Teaching Award UCSF Haile T. Debas Academy of Medical Educators 2017
    First place, Poster Competition Society for Vascular Surgery Annual Meeting 2011

    Clinical Expertise

    Aortic Dissection

    Abdominal Aortic Aneurysm

    Carotid Artery Disease

    Complex Limb Revascularization

    Critical Limb Ischemia

    Diabetic Vascular Disease

    Dialysis Access

    Endovascular Aneurysm Repair

    Mesenteric Artery Disease

    Peripheral Artery Disease

    Thoracic Aortic Aneurysm

    Thoracic Outlet Syndrome

    Clinical Trials

    1. Related Conditions: Aneurysm, Abdominal Aortic Aneurysm| Start Date: | End Date:
    2. Related Conditions: Aneurysm| Start Date: | End Date:
    3. Related Conditions: Peripheral Artery Disease, Vascular Disease, Chronic Limb-Threatening Ischemia, Critical Limb Ischemia, MRI, Neuroimaging| Start Date: | End Date:
    4. Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
    5. Related Conditions: Peripheral Artery Disease, Abdominal Aortic Aneurysm, Aneurysm| Start Date: | End Date:
    6. Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
    7. Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
    8. Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
    9. Related Conditions: Peripheral Artery Disease, Cardiovascular Disease, Vascular Disease| Start Date: | End Date:
    10. Related Conditions: Chronic Kidney Disease, Kidney Disease, Arteriovenous Fistula, Fistula| Start Date: | End Date:

    In the News

    August, 12, 2011 | UCSF Vascular & Endovascular Surgery

    Grants and Funding

    • Transfusion Trigger after Operations in High Cardiac Risk Patients | VA Cooperative Studies Program | 2017-10-01 - 2022-02-28 | Role: Co-local Site Investigator
    • Targeted Endovascular Treatment of Inflammation for Vascular Healing in Humans | NIH/NHLBI | 2015-08-18 - 2020-04-30 | Role: Co-Investigator
    • Imaging Substudy, part of "A Phase 2 Study for the Evaluation of Safety and Efficacy of Humacyte's Human Acellular Vessel for Use as a Vascular Prosthesis for Femoro-Popliteal Bypass in Patients With Peripheral Arterial Disease" | Industry | 2016-06-13 - 2020-03-31 | Role: Principal Investigator
    • Randomized, Multicenter, Controlled Trial to Compare Best Endovascular versus Best Surgical Therapy in Patients With Critical Limb Ischemia (BEST-CLI) | NIH/NHLBI | 2014-12-01 - 2019-12-31 | Role: Principal Investigator

    Research Narrative

    Dr. Gasper’s clinical interests include diseases of the aorta and its major branches, aneurysms and peripheral artery disease. Dr Gasper’s research has been focused on translational projects involving vascular physiology and venous remodeling after arteriovenous fistula and lower extremity bypass surgeries. He also been active in research involving pharmacologic therapies to reduce or prevent restenosis and has been involved in pre-clinical studies as well as clinical trials using a novel endovascular approach to deliver therapy to the artery adventitia.

    Publications

    MOST RECENT PUBLICATIONS FROM A TOTAL OF 114
    1. Strict Control of Blood Glucose With an Intravenous Insulin Infusion Decreases the Risk of Post-operative Lower Extremity Weakness After Complex Endovascular Aortic Aneurysm Repair.
      Hiramoto JS, Hoffman M, Gasper W, Reilly L, Chuter T| | PubMed
    2. Multibranched endovascular aortic aneurysm repair in patients with and without chronic aortic dissections.
      Werlin EC, Kaushik S, Gasper WJ, Hoffman M, Reilly LM, Chuter TA, Hiramoto JS| | PubMed
    3. Peripheral Artery Disease Is Associated with a Deficiency of Erythrocyte Membrane n-3 Polyunsaturated Fatty Acids.
      Ramirez JL, Zahner GJ, Spaulding KA, Khetani SA, Hills NK, Gasper WJ, Harris WS, Cohen BE, Grenon SM| | PubMed
    4. Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial).
      Ramirez JL, Gasper WJ, Khetani SA, Zahner GJ, Hills NK, Mitchell PT, Sansbury BE, Conte MS, Spite M, Grenon SM| | PubMed
    5. Leptinemia is Associated With Peripheral ArteryΒ Disease.
      Zahner GJ, Ramirez JL, Spaulding KA, Khetani SA, Gasper WJ, Grunfeld C, Hills NK, Schafer AL, Grenon SM| | PubMed
    6. Long-term durability of multibranched endovascular repair of thoracoabdominal and pararenal aortic aneurysms.
      Walker J, Kaushik S, Hoffman M, Gasper W, Hiramoto J, Reilly L, Chuter T| | PubMed
    7. Radial Artery Tonometry is Associated With Major Adverse Cardiac Events in Patients With Peripheral Artery Disease.
      Ramirez JL, Spaulding KA, Zahner GJ, Khetani SA, Schaller MS, Gasper WJ, Hills NK, Marlene Grenon S| | PubMed
    8. Serum resistin is associated with impaired endothelial function and a higher rate of adverse cardiac events in patients with peripheral artery disease.
      Ramirez JL, Khetani SA, Zahner GJ, Spaulding KA, Schaller MS, Gasper WJ, Hills NK, Schafer AL, Grenon SM| | PubMed
    9. Depression severity is associated with increased inflammation in veterans with peripheral artery disease.
      Hernandez NV, Ramirez JL, Khetani SA, Spaulding KA, Gasper WJ, Hiramoto J, Lindqvist D, Wolkowitz OM, Hills NK, Grenon SM, Zahner GJ| | PubMed
    10. Frailty Is Associated with an Increased Risk of Major Adverse Cardiac Events in Patients with Stable Claudication.
      Schaller MS, Ramirez JL, Gasper WJ, Zahner GJ, Hills NK, Grenon SM| | PubMed