University of California San Francisco

Dr. Warren Gasper
Warren
Gasper
MD

Associate Professor of Surgery,
Division of Vascular and Endovascular Surgery
Department of Surgery, School of Medicine
Chief, Vascular Surgery Section,
San Francisco VA Health Care System
Director, Vascular Integrated Physiology and
Experimental Therapeutics (ViperX)
Associate Director, Vascular Surgery Integrated Residency Program

Academic Office:
400 Parnassus Ave, A581, Box 0222
San Francisco, CA 94143
Tel: 415-353-4366
Email: [email protected] 
Asst: [email protected]

Vascular Surgery Clinic:
400 Parnassus Ave, A501, Box 0957
San Francisco, CA 94143
Tel: 415-353-2357
Fax: 415-353-2669

Vascular Surgery Clinic at SFVA:
4150 Clement Street 
San Francisco, CA 94121
Tel: 415-221-4810 x25496 

    Biography

    My current research interests fall broadly into the categories of vein / vein graft physiology and advanced endovascular aneurysm therapies. Over the past 4 years I have been working with Dr Michael Conte and Dr Christopher Owens in the UCSF Division of Vascular and Endovascular Surgery on several projects involving vein graft physiology, which have lead to several presentations at national meetings as well as publications. We have found that after lower extremity bypass surgery most luminal dilation occurs early (30 days) and is typically complete by 3 months. However, the response is not uniform and it appears that a mixture of local factors (e.g. vein diameter and quality), biologic factors (e.g. preoperative hsCRP levels) and systemic factors (e.g. race, indication for bypass surgery) are involved in the remodeling response.
    My second major area of research interest is advanced endovascular therapies for aortic aneurysms. The development and widespread adoption of endovascular stent-grafts for infrarenal aortic aneurysms and thoracic aortic aneurysms have dramatically reduced the physiologic demands, complication rates and length of hospitalization for patients undergoing infrarenal or thoracic aortic aneurysm repairs compared to open techniques. However, aneurysms of thoracoabdominal, paravisceral and/or pararenal aorta require even more demanding operations with a higher rate of complications and longer hospitalizations. For the past 4 years I have worked with Dr. Timothy Chuter and Dr. Linda Reilly in the UCSF Division of Vascular and Endovascular Surgery to develop the multi-branched endovascular thoracoabdominal aneurysm repair technique. The technique is being studied under an FDA IDE in a CHR-approved study at UCSF and the San Francisco VA. As the co-principal investigator, I am responsible for overseeing the regulatory and subject care activities for the study at the San Francisco VA. This work has included consultations in the outpatient clinic, planning and performing the multi-branched endovascular repairs and analyzing the results of the study.

    Education

    Institution Degree Dept or School End Date
    University of California, San Francisco Vascular Surgeyr Fellowship School of Medicine 2013
    University of California, San Francisco Vascular Surgery Fellowship School of Medicine 2011
    University of California, San Francisco General Surgery Residency School of Medicine 2010
    Univeristy of Maryland, Baltimore M.D. School of Medicine 2003
    Bowdoin College A.B Biochemistry & German 1999

    Awards & Honors

    Award Conferred By Date
    Lim/Thomas Excellence in Teaching Award UCSF Department of Surgery Chief Residents 2018
    Excellence in Teaching Award UCSF Haile T. Debas Academy of Medical Educators 2017
    First place, Poster Competition Society for Vascular Surgery Annual Meeting 2011

    Clinical Expertise

    Aortic Dissection

    Abdominal Aortic Aneurysm

    Carotid Artery Disease

    Complex Limb Revascularization

    Critical Limb Ischemia

    Diabetic Vascular Disease

    Dialysis Access

    Endovascular Aneurysm Repair

    Mesenteric Artery Disease

    Peripheral Artery Disease

    Thoracic Aortic Aneurysm

    Thoracic Outlet Syndrome

    Clinical Trials

    1. Related Conditions: Aneurysm, Abdominal Aortic Aneurysm| Start Date: | End Date:
    2. Related Conditions: Aneurysm| Start Date: | End Date:
    3. Related Conditions: Peripheral Artery Disease, Vascular Disease, Chronic Limb-Threatening Ischemia, Critical Limb Ischemia, MRI, Neuroimaging| Start Date: | End Date:
    4. Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
    5. Related Conditions: Peripheral Artery Disease, Abdominal Aortic Aneurysm, Aneurysm| Start Date: | End Date:
    6. Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
    7. Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
    8. Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
    9. Related Conditions: Peripheral Artery Disease, Cardiovascular Disease, Vascular Disease| Start Date: | End Date:
    10. Related Conditions: Chronic Kidney Disease, Kidney Disease, Arteriovenous Fistula, Fistula| Start Date: | End Date:

    In the News

    August, 12, 2011 | UCSF Vascular & Endovascular Surgery

    Grants and Funding

    • Transfusion Trigger after Operations in High Cardiac Risk Patients | VA Cooperative Studies Program | 2017-10-01 - 2022-02-28 | Role: Co-local Site Investigator
    • Targeted Endovascular Treatment of Inflammation for Vascular Healing in Humans | NIH/NHLBI | 2015-08-18 - 2020-04-30 | Role: Co-Investigator
    • Imaging Substudy, part of "A Phase 2 Study for the Evaluation of Safety and Efficacy of Humacyte's Human Acellular Vessel for Use as a Vascular Prosthesis for Femoro-Popliteal Bypass in Patients With Peripheral Arterial Disease" | Industry | 2016-06-13 - 2020-03-31 | Role: Principal Investigator
    • Randomized, Multicenter, Controlled Trial to Compare Best Endovascular versus Best Surgical Therapy in Patients With Critical Limb Ischemia (BEST-CLI) | NIH/NHLBI | 2014-12-01 - 2019-12-31 | Role: Principal Investigator

    Research Narrative

    Dr. Gasper’s clinical interests include diseases of the aorta and its major branches, aneurysms and peripheral artery disease. Dr Gasper’s research has been focused on translational projects involving vascular physiology and venous remodeling after arteriovenous fistula and lower extremity bypass surgeries. He also been active in research involving pharmacologic therapies to reduce or prevent restenosis and has been involved in pre-clinical studies as well as clinical trials using a novel endovascular approach to deliver therapy to the artery adventitia.

    Publications

    MOST RECENT PUBLICATIONS FROM A TOTAL OF 114
    1. Correction to: The Resolution of Abdominal Pain: an Ominous Sign of Mesenteric Ischemia.
      Strait A, Gasper W, Dhaliwal G| | PubMed
    2. Eptifibatide bridging therapy for staged carotid artery stenting and cardiac surgery: Safety and feasibility.
      Caton MT, Narsinh KH, Baker A, Amans MR, Hetts SW, Rapp JH, Ianuzzi JC, Tseng E, Gasper WJ, Cooke DL| | PubMed
    3. Secondary interventions after fenestrated/branched aneurysm repairs are common and nondetrimental to long-term survival.
      Zettervall SL, Tenorio ER, Schanzer A, Oderich GS, Timaran CH, Schneider DB, Eagleton M, Farber MA, Gasper WJ, Beck AW, Sweet MP, U.S. Fenestrated and Branched Aortic Research Consortium| | PubMed
    4. Risk factors for venous thromboembolism after vascular surgery and implications for chemoprophylaxis strategies.
      Matthay ZA, Flanagan CP, Sanders K, Smith EJ, Lancaster EM, Gasper WJ, Kornblith LZ, Hiramoto JS, Conte MS, Iannuzzi JC| | PubMed
    5. High glucose macrophage exosomes enhance atherosclerosis by driving cellular proliferation & hematopoiesis.
      Bouchareychas L, Duong P, Phu TA, Alsop E, Meechoovet B, Reiman R, Ng M, Yamamoto R, Nakauchi H, Gasper WJ, Van Keuren-Jensen K, Raffai RL| | PubMed
    6. Understanding value and patient complexity among common inpatient vascular surgery procedures.
      Ramirez JL, Lopez J, Sanders K, Schneider PA, Gasper WJ, Conte MS, Sosa JA, Iannuzzi JC| | PubMed
    7. Contemporary Experience with Paravisceral Aortic Aneurysm (PVAAA) Repair in a Tertiary Center.
      Zarkowsky DS, Inman JT, Sorrentino TA, Hiramoto JS, Vartanian SM, Eichler CM, Reilly LM, Gasper WJ, Conte MS| | PubMed
    8. Depression Predicts Non-Home Discharge After Abdominal Aortic Aneurysm Repair.
      Ramirez JL, Zarkowsky DS, Ramirez FD, Gasper WJ, Cohen BE, Conte MS, Grenon SM, Iannuzzi JC| | PubMed
    9. Patients with depression are less likely to go home after critical limb revascularization.
      Ramirez JL, Zahner GJ, Arya S, Grenon SM, Gasper WJ, Sosa JA, Conte MS, Iannuzzi JC| | PubMed
    10. The Resolution of Abdominal Pain: an Ominous Sign of Mesenteric Ischemia.
      Strait A, Gasper W, Dhaliwal G| | PubMed