Biography
My second major area of research interest is advanced endovascular therapies for aortic aneurysms. The development and widespread adoption of endovascular stent-grafts for infrarenal aortic aneurysms and thoracic aortic aneurysms have dramatically reduced the physiologic demands, complication rates and length of hospitalization for patients undergoing infrarenal or thoracic aortic aneurysm repairs compared to open techniques. However, aneurysms of thoracoabdominal, paravisceral and/or pararenal aorta require even more demanding operations with a higher rate of complications and longer hospitalizations. For the past 4 years I have worked with Dr. Timothy Chuter and Dr. Linda Reilly in the UCSF Division of Vascular and Endovascular Surgery to develop the multi-branched endovascular thoracoabdominal aneurysm repair technique. The technique is being studied under an FDA IDE in a CHR-approved study at UCSF and the San Francisco VA. As the co-principal investigator, I am responsible for overseeing the regulatory and subject care activities for the study at the San Francisco VA. This work has included consultations in the outpatient clinic, planning and performing the multi-branched endovascular repairs and analyzing the results of the study.
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California, San Francisco | Vascular Surgeyr Fellowship | School of Medicine | 2013 |
University of California, San Francisco | Vascular Surgery Fellowship | School of Medicine | 2011 |
University of California, San Francisco | General Surgery Residency | School of Medicine | 2010 |
Univeristy of Maryland, Baltimore | M.D. | School of Medicine | 2003 |
Bowdoin College | A.B | Biochemistry & German | 1999 |
Awards & Honors
Award | Conferred By | Date |
---|---|---|
Lim/Thomas Excellence in Teaching Award | UCSF Department of Surgery Chief Residents | 2018 |
Excellence in Teaching Award | UCSF Haile T. Debas Academy of Medical Educators | 2017 |
First place, Poster Competition | Society for Vascular Surgery Annual Meeting | 2011 |
Clinical Expertise
Aortic Dissection
Abdominal Aortic Aneurysm
Carotid Artery Disease
Complex Limb Revascularization
Critical Limb Ischemia
Diabetic Vascular Disease
Dialysis Access
Endovascular Aneurysm Repair
Mesenteric Artery Disease
Peripheral Artery Disease
Thoracic Aortic Aneurysm
Thoracic Outlet Syndrome
Clinical Trials
- Endovascular Exclusion of Thoracoabdominal And/or Paravisceral Abdominal Aortic Aneurysm (NCT00483249)Related Conditions: Aneurysm, Abdominal Aortic Aneurysm| Start Date: | End Date:
- Branched Aortic Arch Study (NCT00488696)Related Conditions: Aneurysm| Start Date: | End Date:
- Intima Versus Adventitia Drug Delivery to Elucidate Mechanisms of Restenosis: Magnetic Resonance Imaging (NCT02807779)Related Conditions: Peripheral Artery Disease, Vascular Disease, Chronic Limb-Threatening Ischemia, Critical Limb Ischemia, MRI, Neuroimaging| Start Date: | End Date:
- The Effects of Omega-3 Fatty Acids Supplementation on Endothelial Function and Inflammation (NCT01310270)Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
- Related Conditions: Peripheral Artery Disease, Abdominal Aortic Aneurysm, Aneurysm| Start Date: | End Date:
- Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
- The Use of Fish Oil to Reduce Inflammation Caused by a Peripheral Vascular Intervention (NCT02096757)Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
- Dexamethasone Infusion to the Adventitia to Enhance Clinical Efficacy After Femoropopliteal Revascularization (NCT01507558)Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
- Endothelial Function and Vein Graft Remodeling (NCT00831090)Related Conditions: Peripheral Artery Disease, Cardiovascular Disease, Vascular Disease| Start Date: | End Date:
- Related Conditions: Chronic Kidney Disease, Kidney Disease, Arteriovenous Fistula, Fistula| Start Date: | End Date:
In the News
Grants and Funding
- Transfusion Trigger after Operations in High Cardiac Risk Patients | VA Cooperative Studies Program | 2017-10-01 - 2022-02-28 | Role: Co-local Site Investigator
- Targeted Endovascular Treatment of Inflammation for Vascular Healing in Humans | NIH/NHLBI | 2015-08-18 - 2020-04-30 | Role: Co-Investigator
- Imaging Substudy, part of "A Phase 2 Study for the Evaluation of Safety and Efficacy of Humacyte's Human Acellular Vessel for Use as a Vascular Prosthesis for Femoro-Popliteal Bypass in Patients With Peripheral Arterial Disease" | Industry | 2016-06-13 - 2020-03-31 | Role: Principal Investigator
- Randomized, Multicenter, Controlled Trial to Compare Best Endovascular versus Best Surgical Therapy in Patients With Critical Limb Ischemia (BEST-CLI) | NIH/NHLBI | 2014-12-01 - 2019-12-31 | Role: Principal Investigator
Research Narrative
Dr. Gasperβs clinical interests include diseases of the aorta and its major branches, aneurysms and peripheral artery disease. Dr Gasperβs research has been focused on translational projects involving vascular physiology and venous remodeling after arteriovenous fistula and lower extremity bypass surgeries. He also been active in research involving pharmacologic therapies to reduce or prevent restenosis and has been involved in pre-clinical studies as well as clinical trials using a novel endovascular approach to deliver therapy to the artery adventitia.
Publications
- Early Opioid Use and Postoperative Delirium Following Open Abdominal Aortic Aneurysm Repair.| | PubMed
- Early and Late Aortic-Related Mortality and Rupture After Fenestrated-Branched Endovascular Aortic Repair of Thoracoabdominal Aortic Aneurysms: A Prospective Multicenter Cohort Study.| | PubMed
- Postdissection aortic aneurysm sac enlargement after fenestrated and branched endovascular aortic aneurysm repair.| | PubMed
- Practice patterns of antiplatelet and anticoagulant therapy after fenestrated/branched endovascular aortic repair.| | PubMed
- Preoperative risk factors for 1-year mortality in patients undergoing fenestrated endovascular aortic aneurysm repair in the US Aortic Research Consortium.| | PubMed
- Prospective randomized pilot trial comparing prophylactic and therapeutic cerebrospinal fluid drainage during complex endovascular thoracoabdominal aortic aneurysm repair.| | PubMed
- Relevance of BEST-CLI trial endpoints in a tertiary care limb preservation program.| | PubMed
- Secondary interventions following open vs endovascular revascularization for chronic limb threatening ischemia in the BEST-CLI trial.| | PubMed
- Predictors of amputation-free survival and wound healing after infrainguinal bypass with alternative conduits.| | PubMed
- Risk factors and associated outcomes of postoperative delirium after open abdominal aortic aneurysm repair.| | PubMed