University of California San Francisco

Sophia Hernandez, MD, MAS

Sophia Hernandez
Sophia Hernandez, MD, MAS

Resident Research Fellow
T32 Surgical Oncology Fellow
General Surgery

[email protected]

Biography

Sophia Hernandez, M.D. is a general surgery resident with the UCSF Department of Surgery. She
is completing her dedicated research years as a T32 Surgical Oncology Research Fellow in the
Maker lab where she is developing novel immunotherapies and delivery systems for the
treatment of colorectal liver metastasis. She completed her undergraduate studies at California
State University, Fullerton where she earned a degree in Biological Science. She continued her
education at UCSF, where she obtained her medical degree and a Master of Advanced Studies
(MAS) in Clinical Research with a focus on Data Science.

Dr. Hernandez has a strong foundation in translational research, data science, and clinical
research. As an undergraduate, she was awarded the California Institute for Regenerative
Medicine (CIRM) Bridges to Stem Cell Research Award where she utilized CRISPR/Cas9
technology to differentiate human embryonic stem cells. During her medical training, she was
awarded the UCSF Summer Explore Scholar Grant to study fetal immune cell activation in
preterm labor under the mentorship of Dr. Tippi Mackenzie. Additionally, as a medical student
she obtained NIH funding as a TL-1 Medical Student Research Fellow to develop a predictive
model to evaluate the malignant potential of pancreatic cystic neoplasms using radiomic
features and cyst fluid analytes under the mentorship of Dr. Kimberly Kirkwood.

Dr. Hernandez aims to integrate her surgical training with her passion for translational research
and clinical trials as an academic surgical oncologist.

Education

Institution Degree Dept or School End Date
University of California, San Francisco MD 06/2021
California State University, Fullerton BS Cell and Developmental Biology 06/2015
University of California, San Francisco MAS Data Science 06/2015

Awards & Honors

Award Conferred By Date
T32 Surgical Oncology Research Fellowship UCSF 2024/2026
TL1 Medical Student Research Fellowship UCSF 2019/2020
California Institute of Regenerative Medicine (CIRM) Bridges to Stem Cell Research Scholar 2013/2014
CSU Program for Education and Research in Biotechnology Presidents' Commission Scholar CSUF 2012

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 26
  1. The science of tumor-infiltrating lymphocytes (TIL): perspectives from the SITC Surgery Committee.
    Coukos G, Donia M, Gastman BR, Goff SL, Gros A, Harari A, Hernandez S, Ito F, Maker AV, Mullinax JE, Murthy P, Pai SI, Prabhakaran S, Restifo NP, Silver NL, Marincola Smith P, Turcotte S, Wagner PL, Yang JC, Lotze MT| | PubMed
  2. Combination LIGHT overexpression and checkpoint blockade disrupts the tumor immune environment impacting colorectal liver metastases.
    Keenan BP, Qiao G, Kunda N, Kone L, Guldberg SM, Todeschini L, Kumar P, Pollini T, Hernandez S, Qin J, Fong L, Spitzer MH, Prabhakar BS, Maker AV| | PubMed
  3. Minimally Invasive Versus Open Resection for Solid Pseudopapillary Tumors of the Pancreas: A Propensity Score-Matched Analysis.
    Wong P, Todeschini L, Pollini T, Hernandez S, Zampese M, Aguilar LL, Peng JS, Thornblade LW, Adam MA, Alseidi A, Corvera CU, Hirose K, Kirkwood KS, Nakakura EK, Maker AV| | PubMed
  4. Novel Computational Analysis Identifies Cytotoxic Lymphocyte-to-Monocyte Balance in Tumors as a Predictor of Recurrence-Free Survival in Colorectal Carcinoma.
    Fernandez M, Todeschini L, Keenan BP, Rosenberg D, Hernandez S, Zampese M, Qiao G, Pollini T, Maker AV| | PubMed
  5. ASO Author Reflections: Precision Immunoprofiling of the Tumor Microenvironment Predicts Recurrence in Advanced Colorectal Cancer.
    Todeschini L, Hernandez S, Maker AV| | PubMed
  6. Impact of coronary artery stenting on perioperative mortality and complications in patients undergoing pancreaticoduodenectomy.
    Wong P, Tran TB, Pollini T, Hernandez S, Zampese M, Todeschini L, Aguilar LL, Maker VK, Maker AV| | PubMed
  7. Ongoing Failure to Deliver Guideline-Concordant Care for Patients with Pancreatic Cancer.
    Ejie J, Ashraf Ganjouei A, Hernandez S, Wang JJ, Romero-Hernandez F, Foroutani L, Hirose K, Nakakura E, Corvera CU, Alseidi A, Adam MA| | PubMed
  8. Increasing the use of language-concordant discharge instructions in general surgery: A resident-led quality improvement initiative.
    Baskin AS, Romero-Hernandez F, Trang K, Cevallos J, Hernandez S, Colley A, Record H, Dao J, Soriano I, Bongiovanni T, Wick E| | PubMed
  9. Implementation, evaluation, and modification of a near-peer learning group in graduate surgical education.
    Conroy PC, Mohamedaly S, Karimzada M, Brian R, Im C, Hernandez S, Roman S, Hirose K, Mukhtar R, Kirkwood K, O'Sullivan P, Alseidi A| | PubMed
  10. Accurate Identification of Mucinous Pancreatic Cystic Lesions Using Small-Volume Analytes.
    Caiazza F, Conroy PC, Ivry SL, York T, Lin J, Hernandez S, Hoffmann TJ, Francis SS, Park WG, Yip-Schneider MT, Schmidt CM, Brand R, Craik CS, Kirkwood K| | PubMed
  11. The Association of Limited English Proficiency With Morbidity and Mortality After Trauma.
    Castro MRH, Schwartz H, Hernandez S, Calthorpe L, Fernández A, Stein D, Mackersie RC, Menza R, Bongiovanni T| | PubMed
  12. Association of Race/Ethnicity With Substance Use Testing After Trauma: A Cross-Sectional Study.
    Hernandez S, Menza R, Schwartz H, Ledesma Y, Stein DM, Mackersie R, Bongiovanni T| | PubMed
  13. Third year medical student knowledge gaps after a virtual surgical rotation.
    Hernandez S, Song S, Nnamani Silva ON, Anderson C, Kim AS, Campbell AR, Kim EH, Alseidi A, Wick EC, Sosa JA, Gosnell J, Lin MYC, Roman SA| | PubMed
  14. Comparison of advanced techniques for local excision of rectal lesions: a case series.
    Schwab ME, Hernandez S, Watanaskul S, Chern H, Varma M, Sarin A| | PubMed
  15. Screening for Primary Aldosteronism is Underutilized in Patients with Obstructive Sleep Apnea.
    Conroy PC, Hernandez S, Graves CE, Menut KC, Pearlstein S, Liu C, Shen WT, Gosnell J, Sosa JA, Roman S, Duh QY, Suh I| | PubMed
  16. Advocating for a New Residency Application Process: A Student Perspective.
    Badiee RK, Hernandez S, Valdez JJ, NnamaniSilva ON, Campbell AR, Alseidi AA| | PubMed
  17. Bursting the Hidden Curriculum Bubble: A Surgical Near-Peer Mentorship Pilot Program for URM Medical Students.
    Hernandez S, Nnamani Silva ON, Conroy P, Weiser L, Thompson A, Mohamedaly S, Coe TM, Alseidi A, Campbell AR, Sosa JA, Gosnell J, Lin MYC, Roman SA| | PubMed
  18. Evidence-based Guidelines on the Use of Virtual Surgical Education Pertaining to the Domains of Cognition and Curriculum, Psychomotor Skills Training, and Faculty Development and Mentorship.
    Park KM, Rashidian N, Anderson C, Brian R, Calthorpe LM, Gee D, Hernandez S, Lau J, Nepomnayshy D, Patel NM, Pei K, Reddy RM, Roman SA, Scott DJ, Alseidi A| | PubMed
  19. Surviving traumatic injury, only to die of acute drug poisoning: Should trauma centers be a path for intervention?
    Bongiovanni T, Hernandez S, Ledesma Y, Menza R, Wick E, Steinman M, Mackersie R, Stein DM, Coffin PO| | PubMed
  20. Paying it forward: A pilot program for near-peer support for medical students during the surgery clerkship.
    Weiser L, Nnamani Silva ON, Thompson A, Hernandez S, Kelly YM, Kim EH, Campbell AR, Sosa JA, Gosnell J, Alseidi A, Lin MYC, Roman SA| | PubMed
  21. Patient Perceptions on Barriers and Facilitators to Accessing Low-acuity Surgery During COVID-19 Pandemic.
    Johnson CL, Schwartz H, Greenberg A, Hernandez S, Nnamani Silva ON, Wong LE, Martins DB, Broering JM, Kumar SB, Bongiovanni T, Wick EC, Roman SA| | PubMed
  22. Where Do We Go From Here? Assessing Medical Students' Surgery Clerkship Preparedness During COVID-19.
    Nnamani Silva ON, Hernandez S, Kim AS, Campbell AR, Kim EH, Alseidi A, Wick EC, Sosa JA, Gosnell J, Lin MYC, Roman SA| | PubMed
  23. Near-Peer Learning During the Surgical Clerkship: A Way to Facilitate Learning After a 15-Month Preclinical Curriculum.
    Hernandez S, Nnamani Silva ON, Lin MYC, Kim EH, Sosa JA, Campbell AR, O'Sullivan PS, Roman SA| | PubMed
  24. Surgery Clerkship Curriculum Changes at an Academic Institution during the COVID-19 Pandemic.
    Nnamani Silva ON, Hernandez S, Kim EH, Kim AS, Gosnell J, Roman SA, Lin MYC| | PubMed
  25. In vivo blunt-end cloning through CRISPR/Cas9-facilitated non-homologous end-joining.
    Geisinger JM, Turan S, Hernandez S, Spector LP, Calos MP| | PubMed
  26. Manganese (Mn) oxidation increases intracellular Mn in Pseudomonas putida GB-1.
    Banh A, Chavez V, Doi J, Nguyen A, Hernandez S, Ha V, Jimenez P, Espinoza F, Johnson HA| | PubMed