University of California San Francisco

Lucas Wachsmuth, MD, PhD

Lucas Wachsmuth
Lucas Wachsmuth, MD, PhD

Resident (PGY-2)
General Surgery

[email protected]

Education

Institution Degree Dept or School End Date
Duke University MD, PhD Tumor Immunology 05/2025
University of Georgia BS Biochemistry, Biology 05/2014

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 22
  1. Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity.
    Hoyt-Miggelbrink AM, Waibl Polania J, Wachsmuth L, Lorrey S, Mohan A, Hardigan A, Blandford E, Lerner E, Wilkinson D, Hotchkiss KM, Cook S, Hemmers S, Patel A, Ayasoufi K, Fecci P| | PubMed
  2. Adapting Laser Interstitial Thermal Therapy for the Treatment of Naturally Occurring Intracranial Tumors in Dogs.
    Mariani CL, Wachsmuth LP, Bramall AN, Meritet DM, Hatfield J, Tsvankin V, Keenihan EK, Tokarz DA, Tyc R, Nolan MW, Fecci PE| | PubMed
  3. Autonomic modulation of the immune response and implications for CNS malignancies.
    Wachsmuth LP, Srinivasan ES, Puviindran BJ, Haskell-Mendoza AP, DeSpenza T, Fecci PE| | PubMed
  4. Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion.
    Waibl Polania J, Hoyt-Miggelbrink A, Tomaszewski WH, Wachsmuth LP, Lorrey SJ, Wilkinson DS, Lerner E, Woroniecka K, Finlay JB, Ayasoufi K, Fecci PE| | PubMed
  5. Combination checkpoint blockade and laser interstitial thermal therapy in radiographically progressive non-small cell lung cancer brain metastases.
    Haskell-Mendoza AP, Srinivasan ES, Gonzalez AT, Reason EH, Jackson JD, Flusche AM, Wachsmuth LP, Lerner E, Underwood D, Buckley ED, Zaidi SE, Herndon JE, Fecci PE| | PubMed
  6. The LITT Fit in neuro-oncology: indications, imaging, and adjunctive therapies.
    Haskell-Mendoza AP, Gonzalez AT, Reason EH, Flusche AM, Chongsathidkiet P, Wachsmuth LP, Goodwin CR, Fecci PE| | PubMed
  7. NUTMEG: A randomized phase II study of nivolumab and temozolomide versus temozolomide alone in newly diagnosed older patients with glioblastoma.
    Sim HW, Wachsmuth L, Barnes EH, Yip S, Koh ES, Hall M, Jennens R, Ashley DM, Verhaak RG, Heimberger AB, Rosenthal MA, Hovey EJ, Ellingson BM, Tognela A, Gan HK, Wheeler H, Back M, McDonald KL, Long A, Cuff K, Begbie S, Gedye C, Mislang A, Le H, Johnson MO, Kong BY, Simes JR, Lwin Z, Khasraw M| | PubMed
  8. Gold Nanostars Obviate Limitations to Laser Interstitial Thermal Therapy (LITT) for the Treatment of Intracranial Tumors.
    Srinivasan ES, Liu Y, Odion RA, Chongsathidkiet P, Wachsmuth LP, Haskell-Mendoza AP, Edwards RM, Canning AJ, Willoughby G, Hinton J, Norton SJ, Lascola CD, Maccarini PF, Mariani CL, Vo-Dinh T, Fecci PE| | PubMed
  9. CD8+ T cells maintain killing of MHC-I-negative tumor cells through the NKG2D-NKG2DL axis.
    Lerner EC, Woroniecka KI, D'Anniballe VM, Wilkinson DS, Mohan AA, Lorrey SJ, Waibl-Polania J, Wachsmuth LP, Miggelbrink AM, Jackson JD, Cui X, Raj JA, Tomaszewski WH, Cook SL, Sampson JH, Patel AP, Khasraw M, Gunn MD, Fecci PE| | PubMed
  10. Foxn1 overexpression promotes thymic epithelial progenitor cell proliferation and mTEC maintenance, but does not prevent thymic involution.
    Li J, Wachsmuth LP, Xiao S, Condie BG, Manley NR| | PubMed
  11. Posttransplantation cyclophosphamide expands functional myeloid-derived suppressor cells and indirectly influences Tregs.
    Fletcher RE, Nunes NS, Patterson MT, Vinod N, Khan SM, Mendu SK, Li X, de Paula Pohl A, Wachsmuth LP, Choo-Wosoba H, Eckhaus MA, Venzon DJ, Kanakry CG| | PubMed
  12. Systemic immune derangements are shared across various CNS pathologies and reflect novel mechanisms of immune privilege.
    Lorrey SJ, Waibl Polania J, Wachsmuth LP, Hoyt-Miggelbrink A, Tritz ZP, Edwards R, Wolf DM, Johnson AJ, Fecci PE, Ayasoufi K| | PubMed
  13. Erratum to "E.C. Lerner, E.S. Srinivasan, G. Broadwater, et al. Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases. Adv Radiat Oncol. 2022;7:101054."
    Lerner EC, Srinivasan ES, Broadwater G, Haskell-Mendoza AP, Vaios EJ, Edwards RM, Wachsmuth LP, Huie D, Floyd SR, Adamson JD, Fecci PE| | PubMed
  14. Efflux capacity and aldehyde dehydrogenase both contribute to CD8+ T-cell resistance to posttransplant cyclophosphamide.
    Patterson MT, Nunes NS, Wachsmuth LP, Panjabi A, Fletcher RE, Khan SM, Dimitrova D, Kanakry JA, Luznik L, Kanakry CG| | PubMed
  15. Non-inferiority of fragmented care for high-risk pediatric neuroblastoma patients: a single institution analysis.
    Tarnasky AM, Achey MA, Wachsmuth LP, Williamson H, Thomas SM, Commander SJ, Leraas H, Driscoll T, Tracy ET| | PubMed
  16. Grief in Medical Students: The Short and Long-Term Impacts on Health and Well-Being.
    Price MJ, Wachsmuth LP, Ferguson KA, Robbins-Welty GA, Riordan PA, Pieper CF, Galanos A| | PubMed
  17. Hepatic vascular malignancies in children are associated with increased rates of surgical resection and improved overall survival compared with adults.
    Commander SJ, Cerullo M, Leraas HJ, Reed CR, Achey MA, Wachsmuth LP, Schooler GR, Tracy ET| | PubMed
  18. A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy.
    Theivanthiran B, Evans KS, DeVito NC, Plebanek M, Sturdivant M, Wachsmuth LP, Salama AK, Kang Y, Hsu D, Balko JM, Johnson DB, Starr M, Nixon AB, Holtzhausen A, Hanks BA| | PubMed
  19. Optimized Timing of Post-Transplantation Cyclophosphamide in MHC-Haploidentical Murine Hematopoietic Cell Transplantation.
    Wachsmuth LP, Patterson MT, Eckhaus MA, Venzon DJ, Kanakry CG| | PubMed
  20. Post-transplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression.
    Wachsmuth LP, Patterson MT, Eckhaus MA, Venzon DJ, Gress RE, Kanakry CG| | PubMed
  21. Do Biology Students Really Hate Math? Empirical Insights into Undergraduate Life Science Majors' Emotions about Mathematics.
    Wachsmuth LP, Runyon CR, Drake JM, Dolan EL| | PubMed
  22. The Ty1 Retrotransposon Restriction Factor p22 Targets Gag.
    Tucker JM, Larango ME, Wachsmuth LP, Kannan N, Garfinkel DJ| | PubMed